AI-CPD Non-pharma protein design

Proteins,
AI‑redesigned
by computation.

Nobel-Prize-winning AI computational protein design, applied to the $180B+ non-pharma world — feed, food, dairy and industrial enzymes.

$180B+
addressable market beyond pharma
~2 yrs
to first revenues
4
lead proteins in the pipeline
Mission

We design protein super-variants by AI-CPD (Computational Protein Design) — better stability, lower cost, and improved function compared to market products — and bring them to industry through precision fermentation and partnerships.

Explore

How Foldwise works.

Two proven technologies, one team built to move a novel protein variant from AI-computation to the global market.

AI-CPD The designer protein factory

AI Computational protein design,
built for industry.

Computational protein design earned the 2024 Nobel Prize in Chemistry. Foldwise applies this proven technology to the everyday proteins and enzymes the industry already depends on — designing variants that hold up under real manufacturing conditions and significantly cost less to produce.

Design goals

What a designer protein delivers.

Extremophile

Stability

Engineered to withstand heat, pH, acidity and fat content — the conditions that break ordinary proteins on the production line.

Cheap

Lower cost of goods

Fast folding, low aggregation/precipitation, high titer, and excretion from the cell for cheaper purification — driving down cost per unit.

Function

Improved function

Activity that can be altered, broadened, or narrowed to fit the exact application.

Hypoallergenic

Cleaner by design

Designed without allergenic regions and without potentially-harmful impurities.

Scalable

Production-fit

Built from the start to scale to the volume the market needs.

Green

Environmentally friendly

Clean production that fits precision fermentation and sustainability goals.

Method

From knowledge and data to a better protein.

Modern AI-CPD changes whole regions of a protein at once — substitutions, insertions and deletions — guided by a combination of human expertise and machine learning, rather than testing one amino acid at a time.

RATIONAL

Expert-guided design

Decades of structural and biochemical knowledge define which regions to change and why, supported by physics-based comprehensive computational dynamic simulations.

DATA-DRIVEN

AI & combinatorial search

Machine-learning and combinatorial algorithms explore vast sequence space and predict which variants will fold, function and stay stable.

CYCLE

A loop that gets smarter

Each round of lab data feeds back into the model, sharpening the next round of predictions for stability and performance.

Pipeline First target

Starting where the impact is largest.

A comprehensive business-intelligence and technology study screened the leading non-pharma proteins for design potential, market size and route to commercialization. Our first programs target cornerstone large-market proteins for industrial, food and feed applications, where even modest gains in stability and cost of goods translate into value across the entire supply chain. Further targets across food, dairy and industrial applications follow.

Production Precision fermentation

Designer proteins, produced cleanly at scale.

A designed protein only matters if it can be made affordably and at volume. Foldwise products are 100% proteins manufactured by precision fermentation — a clean, scalable process that grows our proteins in microorganisms instead of extracting them from animals or plants, or synthesizing them from chemicals.

Process

From designed sequence to finished protein.

The same proteins we design computationally are produced through a well-established fermentation workflow, optimized for cost of goods at every step.

01

Strain engineering

The designed protein's sequence is built into a production microorganism – yeast, fungi or bacteria
selected for yield.

02

Fermentation

The microorganisms grow in fermenters, expressing the target protein – scaling from shake flask to industrial stainless-steel tanks.

03

Recovery & purification

Proteins designed for excretion are recovered from the broth with fewer, cheaper purification steps.

04

Formulation

The purified protein is stabilized and formulated for its end use – feed pellets, food, detergents or dairy.

Why it matters

A cleaner, cheaper way to make proteins.

Clean & sustainable

Replaces chemical inputs and reduces energy, waste and biocide use — aligned with EPA Green Chemistry, WHO and UN SDG guidance.

Scalable economics

Fermentation scales predictably, and proteins designed for high titer and easy recovery keep cost of goods low as volume grows.

Consumer-ready

Precision-fermented proteins are widely accepted as GMO-free in the final product, and enable vegetarian, halal and kosher options.

Team Five disciplines, one team

The people behind Foldwise.

A rare founding team of startup and multinational leaders covering every discipline required to move a novel protein to the global market — from AI protein design via industrial-scale production and regulation to market launch, business development, and large-scale commercialization.

Ilan Samish

Ilan Samish

Co-founder & CEO

Founder & CEO of Amai Proteins (2016–2025) and creator of the FDA-cleared sweet protein sweelin®. Published the field's foundational textbook on computational protein design.

Dr. Ilan Samish founded Amai Proteins in 2016 to produce hyper-sweet designer proteins by biotechnology. Amai's AI-CPD platform produced sweelin®, a serendipity-berry sweet protein enabling 40–70% sugar reduction with no compromise on taste, health, cost or sustainability — with a double-blind clinical trial showing no effect on blood sugar or insulin, and FDA clearance achieved.

He gained his CPD expertise as an EMBO and HFSP fellow during postdoctoral work at the University of Pennsylvania, in the labs of Prof. Jeffery Saven and Prof. William DeGrado — who established the field of protein design — where he built an algorithm leading to the first de novo designed membrane transporter. He earned his PhD at the Weizmann Institute, deciphering structure–function relationships of membrane proteins, with a Nature publication on photosynthesis along the way.

In 2017 he published Computational Protein Design (Springer, MiMB 1529) — the first book with that title and a field standard, now with 90k+ accesses — and he founded and co-chairs 3Dsig, the leading meeting in structural computational biology.

Naama Kopelman

Naama Kopelman

Co-founder & CTO

Professor of Computer Science who led computational protein design, IP and variants pipeline and bioassay R&D at Amai Proteins. 22 years across genomes, proteins and computational biology.

Dr. Naama Kopelman brings 22 years in academia and education, researching genomes, proteins and computational-biology algorithms across both applied and theoretical work. Her publications in computational and algorithmic biology have received over 5,000 citations.

She joined Amai Proteins in 2021 as Director of Computational Protein Design, soon taking on the company's Intellectual Property department and then most of its R&D — leading experimental design and oversight of the Food Technology department.

A graduate of Tel Aviv University's Adi Lautman Interdisciplinary Program for outstanding students, she holds an MSc from the Weizmann Institute and a PhD from Tel Aviv University and Stanford. Her postdoctoral work developed computational tools for statistical learning of biological data; she later joined the Bioinformatics unit at the Weizmann Institute and a tenure track at the Holon Institute of Technology, teaching and developing courses in Data Science and AI.

Mauricio Adade

Mauricio Adade

Co-founder

Global white-biotech leader since 1988. Former President of DSM's global Human Nutrition & Health business, CMO of Royal DSM, and President of LATAM.

Brazilian/German food engineer (UNICAMP) with an MBA from ESPM, São Paulo. Mauricio began at Roche/Royal DSM in 1988 and rose through Director of Human Nutrition & Health roles in Mexico and Asia-Pacific to Vice President of the Global Food & Pharmaceutical Industry Unit at Roche Vitamins in Basel.

After DSM's acquisition of Roche Vitamins, he became EVP and Head of Global Marketing Nutritional Products, then the first President of DSM's global Human Nutrition & Health business, later Chief Global Marketing Officer of Royal DSM, and in 2015 CEO and President of Latin America — leading 2,000+ people and revenues exceeding US$1.2B across 16 countries.

He has served as Global President of Malnutrition Partnerships & Programmes and Chairman of Africa Improved Foods (Rwanda), and today founded and leads MMA Mentoring and Consulting, alongside numerous board and advisory roles in nutrition and sustainability.

Luca Rosetto

Luca Rosetto

Co-founder

Almost 40 years in pharma/nutrition operations. Former Executive VP Operations and Executive Committee member at DSM; founder of Rosetto Consulting.

A chemist by training, Luca Rosetto began at Dow before spending more than 27 years at DSM (from Gist-Brocades). He held senior roles from a fermentation site in Capua, Italy — which he transformed into a CMO unit — through Director of Safety, Health & Compliance and Business Unit Director Europe/Americas, with full P&L responsibility over ~€230M in annual sales.

After four years as VP Corporate Operations and Responsible Care at DSM HQ, he became Senior VP Operations for DSM Nutritional Products in Kaiseraugst, following DSM's acquisition of Roche Vitamins & Fine Chemicals — ending his corporate career in 2023 as Executive VP Operations and a member of the DSM Executive Committee.

In 2023 he founded Rosetto Consulting (Therwil, Switzerland), collaborating with startups across the pharma and nutritional-ingredients space.

Contact

Let's talk.

We're partnering with producers, investors and manufacturers ready to bring AI-designed proteins to their markets. Reach out and we'll get back to you.

Partnerships

Feed, food, dairy & industrial enzyme producers.

Based in

Israel — working globally.

Email the team →